Colorectal carcinogenesis in germ-free and conventionally reared rats: Different intestinal environments affect the systemic immunity.

Abstract

We can assume that GF rats have a better capability to elicit anticancer immune response than CV animals, and that the immunological challenge produced by the intestinal microbiota and its products can develop a double-edged effects on cancer development

Keywords

• Colorectal
• cancer
• immunity
• rat model