Intrarenal cytochrome P-450 metabolites of arachidonic acid in the regulation of the nonclipped kidney function in two-kidney, one-clip Goldblatt hypertensive rats

Abstract

The contribution of epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE) as cytochrome P-450 metabolites of arachidonic acid in the regulation of the nonclipped kidney function in two-kidney, one-clip (2K1C) Goldblatt hypertensive rats was investigated during the phases of initial and stable hypertension, that is, 7 or 27 days after clipping, respectively.

Keywords

• 20-hydroxyeicosatetraenoic acid
• cytochrome P- 450 metabolites
• epoxyeicosatrienoic acids
• renal function
• renin - angiotensin system
• two - kidney one clip Goldblatt hypertension