Evaluation of Genetic Association and Expression Reduction of TRPC1 in the Development of Diabetic Nephropathy

Abstract

The TRPC1 gene on chromosome 3q22-24 resides within the linkage region for diabetic nephropathy (DN) in type 1 (T1D) and type 2 diabetes mellitus (T2D). A recent study has demonstrated that TRPC1 expression is reduced in the kidney of diabetic ZDF- and STZ-treated rats.

The present study aimed to evaluate the genetic and functional role of TRPC1 in the development of DN.

Keywords

• TRPC1 gene
• single-nucleotide polymorphism
• diabetic nephropathy
• end-stage renal disease
• diabetes types 1 and 2
• stage renal-disease
• susceptibility locus
• african-americans
• candidate genes
• chromosome 3q
• type-1
• kidney
• progression
• mechanisms