N-Acetyl Cysteine Averted Liver Transplantation in a Patient with Liver Failure Caused by Erythropoietic Protoporphyria

Abstract

In patients with EPP, reduced ferrochelatase activity results in an increase of PP in erythrocytes, plasma, liver, and feces. As use of N-acetyl cysteine (NAC) in acute liver failure of toxic etiology has been reported, albeit with inconsistent results, we sought to investigate whether highdose intravenous NAC might be beneficial in the setting of severe liver dysfunction in EPP.

Keywords

• acetylcysteine
• model