Inhibition of the Cryptosporidium parvum S-adenosylhomocysteine hydrolase with purine nucleoside analogues

Abstract

Enzymes af AdoMet cycle, especially S-adenosylhomocysteine hydrolasehave been studied as potential drug target. D-eritadenine, S-DHPA and Ara-A exhibit inhibition of Cryptosporidium parvum.

Keywords

• S-adenosylhomocysteine hydrolase
• inhibition
• D-eritadenine
• S-DHPA
• Ara-A
• Cryptosporidium parvum