Notch signalling regulates fibroblast activation and collagen release in systemic sclerosis

Abstract

It was shown that Notch signalling is activated in SSc and plays an important role in fibroblast activation and collagen release. Inhibition of Notch signalling might be an effective strategy to selectively prevent the aberrant activation of SSc fibroblasts.

Keywords

• ALAGILLE-SYNDROME
• DERMAL FIBROSIS
• HUMAN JAGGED1
• EXPRESSION
• CELLS
• PATHWAY
• PROGRESSION
• INHIBITION
• MUTATIONS
• PROMOTES