Publication at First Faculty of Medicine |
2012
Abstract
Recently, there has been a significant increase of knowledge regarding the pathogenesis and genetic changes occurring in carcinomas of the female genital tract and also regarding the definition of their precursors. A dualistic model of endometrial carcinogenesis hasbeen accepted for a long period of time.
Recently, a similar concept has been proposed for ovarian carcinomas. A correct definition of cancer precursors is important for the understanding of tumor pathogenesis.
Moreover, it has an impact on the prevention and therapy of these tumors.