Effects of Ropinirole Prolonged-Release on Sleep Disturbances and Daytime Sleepiness in Parkinson Disease

Abstract

This study evaluated the effects of ropinirole prolonged-release (RPR) in comparison with ropinirole immediate-release (RIR) on sleep-related disorders in Parkinson disease (PD). After switching to ropinirole prolonged-release, patients reported significantly improved sleep quality and less daytime sleepiness according to following questionnaires: Epworth sleepiness scale, Parkinson's disease sleep scale and Pittsburgh sleep quality index.

Moreover, 13 patients reported disappearance of sleep attacks.

Keywords

• Parkinson disease
• ropinirole
• sleep disorder
• polysomnography
• excessive daytime somnolence
• periodic leg movements
• dopamine agonists
• behavior disorder
• instrument
• actigraphy
• scale
• questionnaire
• cabergoline
• dysfunction
• somnolence