Infection of the lower urinary tract and genital tract in men such as urethritis, prostatitis, epididymitis, orchitis and cystitis are still current, despite they do not pose the greatest share of urological problematic. Every urologist should be familiar with the problems, to be able to get oriented among the specifics of antibiotic treatment depending on the type of disease as well as should be aware of the need for complex urinary tract investigation in selected cases, and also investigation and treatment of the partner in sexually acquired diseases.