Identification of Noninvasive Biomarkers for Alcohol-Induced Liver Disease Using Urinary Metabolomics and the Ppara-null Mouse

Abstract

The authors studied alcohol-induced liver disease in Ppara-null mice. Urinary metabolic profile showed that development of alcohol-induced liver disease in Ppara-null mice was associated with elevation of indole-3-lactic acid.

Keywords

• alcohol-induced liver disease
• PPAR alpha
• Ppara-null mouse
• steatosis
• metabolomics
• UPLC-ESI-QTOF-MS
• multivariate data analysis
• biomarker
• indole-3-lactic acid
• PROLIFERATOR-ACTIVATED-RECEPTOR
• RAT-LIVER
• FATTY LIVER
• ALPHA
• GENE
• METABOLISM
• DATABASE
• EXPRESSION
• OXIDATION
• DRINKING