Bioinformatic and biochemical studies point to AAGR-1 as the ortholog of human acid alpha-glucosidase in Caenorhabditis elegans

Abstract

The genome of Caenorhabditis elegans contains four potential orthologs (AAGR 1-4) of human lysosomal acid alpha glucosidase. We were able to define AAGR-1 as the most probable true ortholog of human acid alpha glucosidase.

Keywords

• GH31 family
• alpha-Glucosidase
• Caenorhabditis elegans
• Glycogen storage disease type II
• lysosomal storage disorders
• maltase-glucoamylase
• aspergillus-niger
• pompe-disease
• active-site
• identification
• intermediate
• specificity
• glycosidase
• inhibitors