Time of life in estrogen deficiency is continuously prolonged by aging of population. Acute climacteric sysndrome attached about 75% of women after menopause.
Level and lenth of problems are individual. Prolonged estrogen deficit is connected with uregenital atrophy, postmenopausal osteoporosis and atherosclerosis.
Reccomendation is based on evidence-based datas which show that hormonal therapy in peri and postmenopausal women under 60 year of life could be safety and efficacy.