No significant correlation between the tau protein concentrations and anti-tau antibody levels (serum, CSF or intrathecal) in the multiple sclerosis (MS) group or in the controls was found. Neither the CSF tau concentration or any calculated ratio between tau and anti-tau antibodies differed between MS patients and controls.
The tau protein released into CSF and the anti-tau humoral response are independent processes in MS and are not distinct from other neurological patients.