Contribution of the Beta-ureidopropionase (UPB1) gene alterations to the development of fluoropyrimidine-related toxicity

Abstract

Our results suggest that UPB1 variants may contribute to the development of 5-FU-related toxicity in some FP-treated patients.

Keywords

• beta-ureidopropionase (UPB1)
• beta-alanine synthase
• 5-fluorouracil
• fluoropyrimidines
• denaturing high-performance liquid chromatography (DHPLC)
• toxicity