Revival of aldosterone blockers in the treatment of chronic heart failure and results of the EMPHASIS-HF study

Abstract

Three clinical studies with mineralocorticoid receptor blockers - spironolactone and eplerenone - have clearly shown that aldosterone receptor blockade in chronic heart failure significantly reduces both mortality and morbidity.

Keywords

• Aldosterone receptors
• spironolactone
• eplerenone
• RALES study
• EPHESUS study
• EMPHASIS-HF study