Vitamin D Pathway Genes, Diet, and Risk of Renal Cell Carcinoma

Abstract

Authors investigated genetic polymorphism in connection to vitamine D (VDR, RXRA) and its associations to renal cell carcninoma risk including frequency of dietary intake of vitamin D and calcium rich foods, and occupational ultraviolet exposure among 777 RCC case and 1035 controls from Central and Eastern Europe. Results suggest that variants in the RXRA gene modified the associations observed between RCC risk and calcium and vitamin D intake.

Keywords

• d-receptor gene
• prostate-cancer
• central-europe
• kidney cancer
• ultraviolet-radiation
• colorectal-cancer
• fish consumption
• sun exposure
• polymorphisms
• susceptibility