Abstract
Patients and methods: Women included in this study passed first-trimester examination in the Institute for the Care of Mother and Child. They were followed till the delivery and divided into 5 subgroups according to the course of pregnancy.
Out of the total 88 first-trimester (F) patients, 8 suffered PE (F-PE), 8 GH (F-GH), 19 GDM (F-GDM), 15 GBS (F-GBS), and 38 were physiological pregnancy (F-C). Another group of 67 patients, in which the data were taken just before the delivery (D), was divided into 3 subgroups, D-PE (n=26), D-GH (n=16), and control subgroup D-C (n=25).
In all patients were measured (by a standard ELISA) serum anti-cardiolipin autoantibodies IgG (ACLA-G) and IgM (ACLA-M), and serum PAPP-A (using Cryptor analyzer). In certain part of patients was measured the rheumatoid factor (RF) (Cryptor analyzer).
Results: In the first-trimester group (F), the percentage of ACLA-G positive women was higher in F-PE group as compared with controls. In other pathologies (F-GH, F-GDM and F-GBS) was elevated the percentage of women positive for ACLA-M.
Mean concentration of RF was significantly higher in the F-PE group as compared with F-C group. In the group D, the percentage of women positive to both ACLA-G and ACLA-M was elevated only in the D-PE subgroup.
We also measured concentration of PAPP-A in 50 physiologically pregnant women between 6th and 21st week of pregnancy and constructed a trend line due to identifying of pathological values. We will discuss 2 case reports of autoimmune impairment of pregnancy (SLE).
Conclusions: The occurrence of ACLA-G in the first trimester may indicate the risk of preeclampsia in the further course of pregnancy, while first-trimester ACLA-M are connected rather with the other types of pathology.