Oxytocin and carbetocin effects on spontaneous behavior of male rats: modulation by oxytocin receptor antagonists

Abstract

Behavioral effects of oxytocin and its antagonists after their intraperitoneal application indicate that they penetrate blood brain barriere. The diversity in potency of oxytocin antagonists to inhibit grooming and other behaviors induced by oxytocin suggests that receptors participating in these behaviors may differ in brain localization, receptor conformation and/or in the utilized signaling pathways.

Keywords

• carbetocin
• grooming
• oxytocin
• oxytocin antagonists
• rat
• spontaneous behavior