Low maternal serum matrix metalloproteinase (MMP)-2 concentrations are associated with preterm labor and fetal inflammatory response

Abstract

Objectives: To assess the relationship between maternal and umbilical serum concentrations of matrix metalloproteinases (MMP)-2,8,9, the soluble receptor for advanced glycation end products (sRAGE) and IL-10 and premature delivery and fetal inflammation. Methods: Maternal serum levels of MMPs, sRAGE, IL-10 and C-reactive protein (CRP) were determined in 67 women with preterm labor and in 38 healthy pregnant women of similar gestational age.

Keywords

• IL-6
• IL-10
• matrix metalloproteinases
• preterm labor
• soluble receptor for advanced glycation end products (sRAGE)
• glycation end-products
• soluble receptor
• parturition
• srage
• term
• infection
• membranes
• infection/inflammation
• interleukin-10
• endproducts