Publikace na Matematicko-fyzikální fakulta |
2013
Abstrakt
Recent advances in RNA research and a steady growth of available RNA structures call for bioinformatics methods for handling RNA structural data. Recently, we have introduced SETTER - a fast and accurate method for RNA pairwise structural alignment.
In the present contribution we describe its extension for multiple RNA structure alignment called MultiSETTER. It combines SETTER's decomposition of RNA structures into disjoint fragments with a well known multiple sequence alignment algorithm ClustalW adapted for the structural alignment.
We demonstrate the validity of our approach on the task of automatic classification of RNA structures.