Differential pulse voltammetric determination of paracetamol in tablet and urine samples at a micro-crystalline natural graphite-polystyrene composite film modified electrode
2013
Abstract
A new extremely sensitive method for the determination of paracetamol by differential pulse voltammetry (DPV) using a micro-crystalline natural graphite-polystyrene composite film modified electrode (CFE) was developed. The experimental parameters, such as pH of Britton-Robinson buffer and potentials for regeneration of the electrode surface, were optimized.
Under optimized conditions in Britton-Robinson buffer (pH 4.0), linear calibration curves were obtained in the range of 0.02-100 mu mol l(-1) of paracetamol. The limit of determination was 0.034 mu mol l(-1) which shows high sensitivity of the developed method.
The method was applied for the determination of paracetamol in pharmaceutical formulations and in human urine model samples.