Publication at Faculty of Pharmacy in Hradec Králové |
2013
Abstract
In this study, a new complementary approach was employed for the determination of stoichiometry in 10 iron-chelating agents, including clinically used drugs, by UV-Vis spectrophotometry at relevant pH conditions and compared with the standard Job's method. We reported that this approach was able to determine the stoichiometry in all tested cases.
The major benefit of this method compared to the standard Job's approach seems to be its capability to reveal a reaction stoichiometry in chelators with moderate affinity to iron.