A new class of phosphanucleosides containing a 3-hydroxy-1- hydroxymethylphospholane 1-oxide ring

Abstract

Novel phosphanucleosides containing a 3-hydroxy-1-hydroxymethylphospholane 1-oxide ring were synthesized as compounds with potential biological activity. A double Arbuzov reaction was employed to prepare a phospholene precursor, which was then converted into an epoxide and subsequently into racemic phosphanucleoside via nucleobase construction.

Keywords

• Phosphanucleoside
• Nucleoside analogue
• Phospholane
• Conformation