Publication at Faculty of Pharmacy in Hradec Králové |
2013
Abstract
The study evaluates the micronized poloxamers L(mu)trol micro127 (poloxamer 407) and L(mu)trol micro 68 (poloxamer 188) as lubricants in combination with the dry binders microcrystalline cellulose and spray-dried lactose. Magnesium stearate was employed as the comparative lubricant.
The parameters under study included energy for friction, plasticity, ejection force, tensile strength of tablets, and disintegration time of tablets. The factors of influence were the concentration of lubricants, compression force, and mixing parameters.