Abstrakt
The possibility of regeneration in a damaged central nervous system (CNS) is limited and therapy of CNS diseases accompanied with neuronal loss is problematic. Neurotransplantation-based therapies have a great potential for future treatments of various diseases, not only by replacing missing or malfunctioning cells but mainly by supporting the inner regenerative processes.
Lurcher (Lc) mutant mice represent a model for olivocerebellar degeneration. Heterozygotes suffer from a complete loss of cerebellar Purkinje cells and a secondary reduction of granule cells and inferior olive neuron number.
The aim of this study was to analyze the survival potential and appearance of grafted GFP-positive carcinoma stem cells partially differentiated into neuroprogenitors from the P19 line or cerebellar embryonic tissue (in the form of cell suspension) both transplanted into the cerebellum of Lurcher mutant and healthy control wild type mice.