Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice

Abstract

The role of hepatic vs extrahepatic metabolism of benzo[a]pyrene

Keywords

• DNA adduct formation
• environmental contaminant 3-nitrobenzanthrone
• polycyclic aromatic-hydrocarbons
• anticancer drug ellipticine
• prostaglandin-h synthase
• knockout mice
• pollutant 3-nitrobenzanthrone
• gene-expression
• determines susceptibility
• conditional deletion