Structure/function relationships underlying regulation of FOXO transcription factors

Abstract

Recent advances in structural studies of forkhead transcription factors and the insights they provide into the mechanism of DNA recognition.

Keywords

• FOXO
• forkhead transcription factors
• 14-3-3 protein
• phosphorylation
• acetylation
• ubiquitination
• protein-kinase-b
• winged helix proteins
• dna-binding domain
• insulin-response sequence
• forkhead gene family
• extends life-span
• factor afx foxo4
• crystal-structure
• caenorhabditis-elegans
• nuclear-localization