Aristolochic acid mutagenesis: molecular clues to the aetiology of Balkan endemic nephropathy-associated urothelial cancer

Abstract

Of the many hypotheses on BEN, the Aristolochia hypothesis has recently gained ground substantiated by the investigations on aristolochic acid nephropathy.

Keywords

• chinese herbs nephropathy
• covalent dna adduction
• human p53 gene
• ochratoxin-a
• renal-failure
• risk-factor
• ras gene
• rats
• mutations
• exposure