Large propeptides of fungal beta-N-acetylhexosaminidases are novel enzyme regulators that must be intracellularly processed to control activity, dimerization, and secretion into the extracellular environment

Abstract

Filamentous fungi produce and secrete beta-N-acetylhexosaminidases that can occur in the form of two molecular species containing either one or two molecules of the propeptide noncovalently associated with the enzyme dimer.

Keywords

• peptide-loading complex
• tay-sachs-disease
• extensive homology
• protein
• yeast
• hexosaminidase
• gene
• molecules
• acetylglucosaminidase
• endopeptidase