Modifying the beta,gamma leaving-group bridging oxygen alters nucleotide incorporation efficiency, fidelity, and the catalytic mechanism of DNA polymerase beta

Abstract

Modifying the beta,gamma leaving-group bridging oxygen alters nucleotide incorporation efficiency, fidelity, and the catalytic mechanism of DNA polymerase beta

Keywords

• replication fidelity
• alkaline-phosphatase
• transition-state
• complexes
• hydrolysis
• probes
• stability
• constants
• repair
• acid