DNA polymerase beta catalytic efficiency mirrors the Asn279-dCTP H-bonding strength

Abstract

DNA polymerase beta catalytic efficiency mirrors the Asn279-dCTP H-bonding strength

Keywords

• DNA polymerase beta
• enzyme preorganization
• near attack conformers
• molecular dynamics
• site mutagenesis
• dNTP
• free energy
• nucleotide incorporation
• enzyme catalysis
• fidelity
• simulations
• mechanism
• energies
• repair
• model