Both the N-terminal loop and wing W2 of the forkhead domain of transcription factor FoxO4 are important for DNA binding

Abstract

We investigated the role of the N-terminal loop and the C-terminal region W2 of the forkhead domain of FoxO4 in DNA binding.

Keywords

• resonance energy-transfer
• double-stranded dna
• helix protein
• molecular-dynamics
• crystal-structure
• structural basis
• ligand-binding
• cell-cycle
• factor afx
• phosphorylation