The environmental pollutant and carcinogen 3-nitrobenzanthrone and its human metabolite 3-aminobenzanthrone are potent inducers of rat hepatic cytochromes P450 1A1 and-1A2 and NAD(P) H : quinone oxidoreductase

Abstract

3-Nitrobenzanthrone (3-NBA), a suspected human carcinogen occurring in diesel exhaust and air pollution, and its human metabolite 3-aminobenzanthrone (3-ABA) were investigated for their ability to induce biotransformation enzymes in rat liver and the inf

Keywords

• DNA adduct formation
• nitropolycyclic aromatic-hydrocarbons
• diesel exhaust
• contaminant 3-nitrobenzanthrone
• NAD(P)Hh-quinone oxidoreductase
• human acetyltransferases
• reductive activation
• liver-microsomes
• air-pollution