Type and distribution of indomethacin-induced lesions in the gastrointestinal tract of rat

Abstrakt

The therapy with non-steroidal anti-inflammatory drugs is often accompanied with adverse effects in gastrointestinal tract. Aim of this experimental study was to define the time range of the creation of indomethacin-induced gastrointestinal lesions in rat.

The gradual development of lesions was observed 6 hours in stomach and 24-72 hours in the intestine after the indomethacin administration. Not only the gradual development of pathophysiological alterations was observed but also the reparative phase (in the stomach). 24 hours seem to be advisable time suitable for the evaluation of the probiotics effecs as a potential therapy on the indomethacine-induced gastrointestinal lesions in rats.