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Differential effects of statins and alendronate on cholinesterases in serum and brain of rats

Publikace na Lékařská fakulta v Hradci Králové |
2007

Tento text není v aktuálním jazyce dostupný. Zobrazuje se verze "en".Abstrakt

The aim of the present study was to test classical (statins) and atypical (bisphosphonates) cholesterol-lowering drugs for possible effects on blood acetyl- and butyrylcholinesterase and brain AChE activities with respect to their blood-brain barrier permeability. We conclude that cholesterol-lowering drugs may inhibit AChE activity in brain providing they penetrate blood-brain barrier.