Publikace na Lékařská fakulta v Hradci Králové |
2007
Abstrakt
CVID is a heterogenous group of diseases. The defects of molecules regulating activation and terminal differentiation of B lymfocytes have been described in some patients with CVID.
In this study, we show the overview of deficiencies of ICOS, TACI, CD19 molecules, their genetic basis, pathogenesis and clinical manifestations of humoral deficiency.