Effect of atorvastatin on non-cholesterol sterol in patients with type 2 diabetes mellitus and cardiovascular disease

Abstract

An increased risk of cardiovascular morbidity and mortality in diabetes mellitus type 2 has been associated with disturbance of lipid homeostasis. Recently, decreased intestinal absorption of cholesterol and increased liver cholesterol production have been reported.

We conclude that in spite the total cholesterol level in diabetics type 2 is not increased, its endogenous synthesis is enhanced. Our results show that the diabetics type 2 with increased serum lathosterol and expressed metabolic syndrome (mild increased of triglycerides) might represent a suitable group for intensive treatment with statins.