Homology modeling and SAR analysis of Schistosoma japonicum cathepsin D (SjCD) with statin inhibitors identifies a unique active site steric barrier of potential for the design of specific inhibitors.

Abstract

3D model of cathepsin D from S. japonicum was generated. A set of inhibitors was tested with this model, four of them tested experimentally.

Keywords

• schistosoma
• proteases of parasites
• modelling