New multiple somatic mutations in the RET proto-oncogene associated with a sporadic medullary thyroid carcinoma

Abstract

Medullary thyroid carcinoma (MTC) occurs mostly as a sporadic tumor or in connection with inherited cancer syndromesmultiple endocrine neoplasia (MEN) types 2A and 2B and familial MTC. These both newly described somatic multiple mutations were revealed in a hemizygous status, the loss of heterozygosity in tumor tissues in comparison with germline DNA was confirmed.