Single-dose pharmacokinetics of a novel oral platinum cytostatic drug ([OC-6-43]-bis[acetato][1-adamantylamine]amminedichloroplatinum [IV]) in pigs

Abstrakt

The pharmacokinetics of total platinum (Pt) were investigated after a single oral dose of ([OC-6-43]-bis[acetato][1-adamantylamine]amminedichloroplatinum [IV](LA-12). A dose of 3mg/kg (n=3) and 30 mg/kg (n=3) was given to two parallel groups of pigs.

The mean (SEM) Pt urinary excretion determined over a 6-h postdose period achieved only 1,9% and 0,8% of the administered doses.Platinum recoveries in feces over 10 days after dosing reached 0,4% and 2,6 % of the administered dose, respectively. Pharmacokinetics data for total platinum in pigs agree with those obtained in other experimental species and indicate rapid and efficient absorption and extensive tissue distribution of total platinum after a single dose administration of LA-12.