Comparison of zirconia- and silica-based reversed stationary phases for separation of enkephalins

Abstract

The separation of biologically active peptides on two zirconia-based phases, polybutadiene and polystyrene ZrO2,and a silica-based phase C18 was compared. Basic differences in interactions on both types of phases led to quite different selectivity.

Keywords

• RP-HPLC
• octadecyl silica-based stationary phase
• zirconia-based stationary phase
• peptides
• enkephalin