Human hepatic and renal microsomes, Cytochromes P450 1A1/2, NADPH : Cytochrome P450 reductase and prostaglandin H synthase mediate the formation of aristolochic acid-DNA adducts found in patients with urothelial cancer

Abstract

Formation of aristolochic acid-DNA adducts in patients with urothelial cancer caused by cytochromes P450 1A1/2, NADPH : cytochrome P450 reductase and prostaglandine H synthase

Keywords

• aristolochic acid
• carcinogen
• urothelial cancer
• liver and kidney microsomal enzymes
• activation
• DNA adduct
• P-32 postlabeling