Synthesis of a bifunctional monophosphinic acid DOTA analogue ligand and its lanthanide(III) complexes. A gadolinium(III) complex endowed with an optimal water exchange rate for MRI applications

Abstract

Synthesis of DOTA analogue with one phosphinated pendant arm. The characterization of Ln(III) complexes in the solution.

The Gd(III) complex shows the optimal water exchange rate for an application in MRI thomography.

Keywords

• CONTRAST AGENTS
• MAGNETIC-RESONANCE
• MACROCYCLIC LIGANDS
• COORDINATION ISOMERS
• GD(III) COMPLEXES
• AQUEOUS-SOLUTION
• RATIONAL DESIGN
• O-17 NMR
• SHIFTS
• DIETHYLENETRIAMINE