Relaxant effect of oxime derivatives in isolated rat aorta: role of nitric oxide (NO) formation in smooth muscle

Abstract

In aorta rings, hydroxyguanidine and hydroxyurea were almost inactive, whereas formamidoxime, acetaldoxime, acetone oxime, acetohydroxamic acid and formaldoxime elicited relaxation.

Keywords

• nitric oxide
• nitric oxide synthase
• phenylpherine
• PTIO
• glyceryl trinitrate