3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone, forms DNA adducts after metabolic activation by human and rat liver microsomes: Evidence for activation by cytochrome P450 1A1 and P450 1A2

Abstract

Evidence for metabolic activation of 3-nitrobenzanthrone by cytochrome P450 1A1 and P450 1A2 present in human and rat liver microsomes

Keywords

• CHINESE-HAMSTER CELLS
• PERFORMANCE LIQUID-CHROMATOGRAPHY
• CONTAMINANT 3-NITROBENZANTHRONE
• STABLE EXPRESSION
• DIESEL EXHAUST
• HUMAN ACETYLTRANSFERASES
• POSTLABELING ANALYSIS
• REDUCTIVE ACTIVATION