Diaphorase Can Metabolize Some Vasorelaxants to NO and Eliminate NO Scavenging Effect of 2-Phenyl-4,4,5,5,-tetramethylimidazoline-1-oxyl-3-oxide (PTIO)

Abstract

In the presence of NADH or NADPH, diaphorase can convert selected NO donors, glycerol trinitrate and formaldoxime to nitrites and nitrates with NO as an intermediate.

Keywords

• Formaldoxime metabolism
• Glycerol trinitrate metabolism
• Diaphorase
• 2-phenyl-4,4,5,5,-tetramethylimidazoline-1-oxyl-3oxide(PTIO)reduction