Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases.

Abstract

Aza-peptide Michael acceptors are irreversible inhibitors of clan CD cysteine proteases. Aza-peptide Michael acceptors showed no cross reactivity toward papain, cathepsin B, and calpain.

Keywords

• ASPARAGINYL ENDOPEPTIDASE
• SCHISTOSOMA MANSONI
• EXPRESSION
• APOPTOSIS
• MECHANISM
• LEGUMAIN