The small chemical vacuolin-1 inhibits Ca2+-dependent lysosomal exocytosis but not cell resealing

Abstract

Resealing after wounding, the process of repair following plasma membrane damage, requires exocytosis. Vacuolins are molecules that induce rapid formation of large, swollen structures derived from endosomes and lysosomes by homotypic fusion combined with

Keywords

• chemical genetics
• membrane repair
• exocytosis