Targeted gene replacement of a ferredoxin gene in Trichomonas vaginalis does not lead to metronidazole resistance

Abstract

These data indicate the presence of unidentified Fds or flavodoxins capable of drug activation or an unidentified mechanism that does not require either PFO or Fd for metronidazole activation

Keywords

• HYDROGENOSOMAL FERREDOXIN
• ENTAMOEBA-HISTOLYTICA
• SUPEROXIDE-DISMUTASE
• DRUG-RESISTANCE
• MALIC ENZYME
• OXIDOREDUCTASE
• PYRUVATE
• INVOLVEMENT
• MECHANISMS
• EXPRESSION