(S)-2-chloro-2-fluoroethanoyl isocyanate, a chiral derivative of trichloroacetyl isocyanate

Abstract

Carbamate diastereomers 3b-18b were prepared from easily accessible (S)-2-chloro-2-fluoroethanoyl isocyanate (1) and various secondary chiral alcohols. Compound 1 as a chiral analog of trichloroacetyl isocyanate undergoes the reaction with alcohols very

Keywords

• trichloracetyl isocyanate
• acylisocyanate
• NMR
• chiral analysis
• alcohols
• derivatization
• TAI
• h-1-nmr anisotropy method
• absolute-configuration
• 2-methoxy-2-(1-naphthyl)propionic acid
• chlorofluoroacetic acid
• secondary-amines
• alcohols
• enantioresolution
• assignment
• esters
• agent